- Countries/Regions
- United States of America
- Category
- Research
- Academic Field
- Medicine
- Related goals of SDGs
| Keyword |
SLFN11, brain tumor, epigenetics, DNA damaging agent |
Information on Niigata University
| Name of the professor/researcher |
Manabu Natsumeda |
| Position/Faculty |
Assistant Professor, Department of Neurosurgery, Brain Research Insititute |
Information on the Counterpart
| Countries/Regions |
USA |
| Faculty/Institution |
Johns Hopkins University |
Detailed Information/Report on Activities
Malignant brain tumors, especially those that are resistant to chemotherapy, have dismal prognoses. SLFN11 is a DNA/RNA helicase, whose expression highly correlates with response to DNA damaging agents in cancer. However, the expression of SLFN11 in brain tumors has not been studied to date. The major goal of this research is to investigate the expression of SLFN11 in brain tumors and response to DNA damaging agents. SLFN11 will be upregulated pharmacologically and by using SLFN11 overexpression constructs to increase chemosensitivity in brain tumors with low SLFN11 expression. In collaboration with Department of Pathology, Johns Hopkins University and Institute for Advanced Biosciences, Keio University, comprehensive epigenetic assessment will be performed to elucidate the exact mechanism of SLFN11 upregulation.
