- Countries/Regions
- United States of America
- Category
- Research
- Academic Field
- Medicine
- Related goals of SDGs
| Keyword |
Gli3, medulloblastoma, immunohistochemistry |
Information on Niigata University
| Name of the professor/researcher |
Manabu Natsumeda |
| Position/Faculty |
Assistant Professor, Department of Neurosurgery, Brain Research Institute, Niigata University |
Information on the Counterpart
| Countries/Regions |
United States of America |
| Faculty/Institution |
Department of Pathology, Johns Hopkins University School of Medicine |
Detailed Information/Report on Activities
We investigated the role of Gli3, a downstream transcription factor of the Sonic Hedgehog pathway in the neuronal differention of medulloblastomas. Gli3 immunohistochemistry was performed in two cohorts, Hopkins and Niigata cohorts. Additionally, Nanostring analysis and single cell RNA sequencing were performed. We found that Gli3 is upregulated in WNT- activated and SHH-activated medulloblastomas, leading to neuronal differentiation in these subgroups, and published the results in Journal of Neuropathology and Experimental Neurology.
