- Countries/Regions
- Spain
- Category
- Research
- Academic Field
- Medicine
- Related goals of SDGs
| Keyword |
Genetically modified mice |
Information on Niigata University
| Name of the professor/researcher |
Toshikuni Sasaoka |
| Position/Faculty |
Professor, Brain Research Institute |
Information on the Counterpart
| Countries/Regions |
Spain |
| Faculty/Institution |
CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur, CEU-San Pablo University |
Detailed Information/Report on Activities
Dr. Hernandez is trying to use D1R KO and D2R KO mice to see the role of each pathway separately in optodyskinesia generation. Dr. Hernandez do have D1R KO mice but they die after birth and are too small to survive a Medial Forebrain Bundle lesion with 6-OHDA. They barely reach the 20gr even after 5-6 months of age. We have been trying for more than a year with no success. Therefore, they are interested in conditional D1R KO mice we saw an opportunity to complete this work using those mice. Being able to selectively KO the D1 receptor only during the laser stimulation will answer their question and complete the project.
Dr. Hernandez is interested on studying the D1R role in the optodyskinesias. Dr, Moratalla and collaborators have shown in the past that L-DOPA induced dyskinesias are dependent on striatal D1R. Dr. Hernandez would like to prove that the dyskinesias evoked with laser into medium spiny neurons are also dependent on this receptor.
