- Countries/Regions
- Denmark
- Category
- Research
- Academic Field
- Medicine
- Related goals of SDGs
Information on Niigata University
| Name of the professor/researcher |
Toshikuni Sasaoka |
| Position/Faculty |
Professor, Brain Research Institute |
Information on the Counterpart
| Countries/Regions |
Denmark |
| Faculty/Institution |
Aarhus University |
Detailed Information/Report on Activities
In order to understand circuit mechanisms underlying neurological diseases, it is important first to understand how neuronal computation, which is impaired in relevant disease, is achieved by synaptic and circuit mechanisms in healthy state. Our research purpose is to create several mouse lines in which a single subtype of retinal bipolar cells is genetically labeled. With these mice, we will test the effect of cell-type-specific manipulation of neuronal activity or gene expression on the retinal motion computation and eye movement reflex. Specifically, we aim to understand how retinal ganglion cells compute visual motion by integrating excitatory inputs from retinal bipolar cells, and how impaired function of retinal bipolar cells may lead to impaired retinal motion computation and pathogenic nystagmus.
